OZ Bioscience CNE-CPO Vaccine Adjuvant 5 mL CNE5000

CNE-CPO (Cationic Nano Emulsion) Vaccine Adjuvant is an oil-in-water Cationic Nano Emulsion made of squalene droplets and cationic polymers in a continuous aqueous phase. The cationic components that compose this nano-emulsion make it a genetic adjuvant that allows the association with plasmid DNA to form an efficient nanoparticle delivery system (NPD). NPD are non-viral gene delivery systems, self-assembled from cationic entities and negatively charged immunogen that function as vaccine carrier. CNE-CPO Vaccine Adjuvant is biodegradable, an important advantage over alternative oils that have been used in emulsion adjuvants, like Freund’s adjuvant that contains mineral oil (paraffin oil) and has long term persistence in the organism. CNE induces local stimulation and recruitment of DCs and granulocytes, differentiation of monocytes into DCs and increased uptake of antigen by DCs. The emulsion acts more specifically on macrophages present at the site of injection. A local increase of chemokines released also influences the recruitment of immune cells from the blood to the site of vaccination, creating an amplification loop. This formulation enhances differentiation of monocytes towards a mature phenotype, thereby promoting migration of antigen-loaded cells to the draining lymph node.