OZ Bioscience AlumVax Phosphate vaccine adjuvant 50ML AP0050

AlumVax Phosphate is wet gel (colloidal) of aluminum phosphate 2%, provided as a ready-to-use suspension. Aluminum salts are the most common adjuvants used in approved prophylactic vaccines because of their excellent safety profile and ability to enhance protective humoral immune response. Since more than 80 years, it has been observed that aluminium compounds act by a depot effect and also by direct activation of the immune cells. Adsorption or entrapment of antigens in aggregates through hydrophobic and electrostatic interactions favors a high local antigen concentration and improved uptake by antigen presentating cells (APC). AlumVax phosphate is an amorphous aluminum hydroxyphosphate which is negatively charged at physiological pH (pI=5–7), suitable for adsorption of positively charged or neutral, alkaline proteins.